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Dernière mise à jour : Mai 2018


Laboratory of Plant-Microbe Interactions - LIPM

Laboratory of Plant-Microbe Interactions

Members - Infectious strategies of Xanthomonas

Matthieu Arlat, PRCE, Professor, University Toulouse 3


Matthieu Arlat did his PhD at LIPM in Chris Boucher’s lab where he participated to the identification and the characterization of hrp (type III secretion system) gene cluster in Ralstonia solanacearum. He then moved to the Sainsbury Laboratory in Norwich (United Kingdom) and joined the group of Mike Daniels where he identified Xanthomonas campestris pv campestris hrp gene cluster. In 1991, he was recruited as a scientist at INRA in Chris Boucher’s group. He identified PopA, one of the first type III effector of plant pathogenic bacteria. He also characterized PrhA, the first TonB-dependent transporter (TBDT) involved in the perception of plant signal and controlling hrp genes expression in R. solanacearum. He obtained a Professor position in Microbiology at University Toulouse 3, in 2003. His research focuses on type III secretion systems and metabolic adaptation of Xanthomonas species. He studies the role of TBDT in plant compounds scavenging and their evolution in the bacterial world.



Noe Arroyo Velez, PhD student

Matthieu Arlat

Noe obtained his Master’s degree in Genetics and Molecular Biology in the center for research and advanced studies (Cinvestav) in Mexico City where he studied the assembly of RNA Degradosome in the bacteria E. coli.

He started his PhD at the LIPM in September 2018 aiming to identify the plant targets of Xanthomonas type III effector proteins, in order to elucidate how the pathogen effectome manipulates plant immunity and physiology.


Corinne Audran , CRCN, INRA


Corinne worked on the regulation of abscisic acid biosynthesis during seed development and in response to drought stress during her PhD and post-doc at INRA Versailles. She joined the GBF research lab (Genomics and Fruit Biotechnology) in 2001 as an INRA researcher. She investigated the hormonal control of tomato fruit development focusing on repressors of auxin signaling pathway (Aux/IAA gene family). She joined the LIPM lab in 2015 to elucidate the protective roles of transcriptional regulators of plant defence expressed during early seed development in Arabidopsis thaliana.

Corinne joined us in the fall of 2018. Her project aims at studying transcription-activator-like effectors (TALEs)-mediated susceptibility from the genus of phytopathogenic bacteria Xanthomonas campestris in Arabidopsis and Brassicas.



Caroline Bellenot, Thesis, University Toulouse 3


Caroline obtained her Masters degree in plant biology (Speciality in plant health management) at Angers University. She joined the SIX group for her Masters' internship to study the contribution of Xanthomonas campestris TAL effectors to susceptibility of Brassicaceae to black rot disease.

In january 2019, she started a PhD to explore the genetic and molecular basis of hydathode and vascular immunity against balck rot disease agent Xcc.


Alice Boulanger, Lecturer, University Toulouse 3


Throughout her career, Alice Boulanger has studied, at different levels, host-pathogenic bacteria interactions and virulence traits regulation. During her phD, in Pr. Matthieu Arlat’s team (LIPM-INRA, Toulouse, 2009), her work focused on plant infection and adaptation processes of phytopathogenic bacterium Xanthomonas campestris pathovar campestris (Xcc) and she has characterized a new N-acetylglucosamine (GlcNAc) utilization pathway. She then joined the team of Dr. Deborah Hinton (NIH, Bethesda, USA, 2010) where she worked on molecular characterization of transcription initiation of Bordetella pertussis virulence genes, the agent of whooping cough. In 2013, she joined Dr Mireille Ansaldi team (LCB, UMR7283, Marseille) to identify new master regulators involved in prophages maintenance in enteropathogenic bacteria.

Alice has joined the team in September 2015 as an assistant professor at the University Paul Sabatier (UT3) and will be involved in development of projects that focus on transcriptomic analysis during the infection cycle and characterization of bacterial genetic programs specific to the infection process.



Manuel Gonzalez Fuente, Thesis, University Toulouse 3


Manuel obtained his Masters degree in Agricultural Genomics at the Christian Albrechts University of Kiel (Germany) where he worked on the rapeseed and Arabidopsis thaliana response upon Verticillium longisporum infection at the microRNA level.

He started his PhD at the LIPM in January 2017 working in collaboration with the group "Ralstonia pathogenesis and adaptation to the plant environment" in order to study the evolutionary conservation of plant targets of type III effectors common to Xanthomonas and Ralstonia.


Carine Gris, Technical Assistant, CNRS

Carine Gris

Carine joined the LIPM in 1998 after 15 years spent at the Pasteur Institute in Paris. She was involved in an experimental evolution project until August 2016.

Carine  joined our group in September 2016 to establish and refine the measure of Xanthomonas pathogenicity.



Emmanuelle Lauber, CRCN, CNRS


During her PhD thesis at the IBMP, Strasbourg, Emmanuelle Lauber studied cell-to-cell movement and long distance movement of Beet Necrotic Yellow Vein Virus during plant infection. She then moved to the IBMC, Strasbourg, and studied the first strand transfer during retrotranscription of HIV genomic RNA. In 2000, Emmanuelle joined the group of Frans de Bruijn at the LIPM as a permanent CNRS researcher and participated in the development of Sinorhizobium meliloti micro- and macro-arrays. In 2003, she joined the group of Matthieu Arlat. She is involved in the study of metabolic adaptation of Xanthomonas during infection. Her research is focusing on the role of TonB-dependent transporters in nutrient scavenging.



Julien Luneau, Thesis, University Toulouse 3

Carine Gris

After obtaining his Master’s Degree in agronomy and plant pathology (Agrocampus Ouest Rennes / Université d’Angers), Julien joined the LIPM in October 2017 to start his PhD on the adaptation of the plant pathogenic bacterium Xanthomonas campestris pv. campestris to the environments encountered within the plant during cabbage infection.


Laurent Noël, DR2, CNRS, group leader

laurent NOEL

After a basic training in molecular biology and genetics (ENS Lyon), Laurent NOEL worked on Resistance gene cloning in pepper (Bonas lab, CNRS, Gif/Yvette, France, Master degree) and R gene evolution in Arabidopsis (J. Jones lab, Sainsbury lab, Norwich UK, civil service). He then moved to the analysis of chaperones/cochaperone machinery in establishing plant immunity (Parker lab, Max Planck Institute, Cologne, Germany, Post-doc) and in mediating auxin signalling and abiotic stress tolerance (Nussaume’s lab, CEA, Cadarache, CR2 CNRS). Previously, his PhD work dealt with the identification of the hrp regulon in Xanthomonas (Bonas lab, Martin-luther university, Halle/Saale, Germany) and lead to the identification of novel type III effectors named Xop (Xanthomonas outer proteins). Since 2008, he joined the LIPM to investigate Xop contribution to Xanthomonas virulence and identify plant targets of Xops. He is also exploring Xanthomonas genetic diversity by genomics and transcriptomics to develop genome-wide association studies.

Publications Xantho/Arabidopsis



Jean-Marc Routaboul, Research Scientist, INRA


After a PhD in Plant Biology earned in Grenoble in 1991, Jean-Marc Routaboul has essentially worked on the model plant Arabidopsis using a combination of functional genomic, metabolomics and quantitative genetic approaches.  An early part of his career was dedicated to plant lipids. After a short stay at Louisiana State University (T. Moore), he joined the group of J. Browse at Washington State University in 1994 to study for four years the role of plant polyunsaturated fatty acid for cold and heat stress tolerance. He went then to the group of C. Benning at IGF-Berlin for one year and continued this work from 1998 to 2001 in the team of L. Lepiniec at INRA Versailles where he was among the first to clone the DAGAT gene whose product catalyses the last step in oil synthesis (and fat).  He was hired at INRA in 2003 as a research engineer in the group of L. Lepiniec. He developed there several projects dealing with flavonoid synthesis in Arabidopsis seed especially on the chemical identification of these still poorly studied metabolites and on the genetic bases of their variability. In 2012, he moved to Toulouse and another model plant tomato to focus on the molecular mechanism leading to the development of fruit flesh at the Genomic and Biology of Fruit laboratory. in 2018, he moved back to Arabidopsis and brassicaeae. His current project is to decipher the role of hydathodes in plant immunity. Hydathodes are organs at the leaf margin which are used by Xanthomonas campestris to enter the leaf and cause black rot disease on Brassica.