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24, chemin de Borde Rouge –Auzeville – CS52627
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Dernière mise à jour : Mai 2018


Laboratory of Plant-Microbe Interactions - LIPM

Laboratory of Plant-Microbe Interactions

Members - Symbiotic functions, genome and evolution of rhizobia

Delphine Capela, HDR, CRCN CNRS, group leader

Delphine CAPELA

During her PhD, Delphine brought a major contribution to the sequencing and expert annotation of the genome of the model rhizobium Sinorhizobium meliloti. When she joined the CNRS in the group of Jacques Batut’s in 2002 she pursued the work on the postgenomics of S. meliloti in deciphering the transcriptome of S. meliloti during the symbiotic process and in free living conditions. Microarray was at that time the most powerful tool to study microbial transcriptomes. More recently, in collaboration with other groups in the lab, Delphine revisited the transcriptome of S. meliloti during symbiosis with Medicago truncatula using deep sequencing of RNAs. In 2008, the main research work of Delphine switched to the experimental evolution project which aims at converting a non-symbiotic bacterium into a legume symbiont. In this project, she is managing the production of evolved populations and clones and is seeking for adaptive mutations responsible for the improvement of the symbiotic properties of experimentally evolved strains.


Catherine Masson-Boivin, HDR, DR1 INRAE

Catherine Masson

Catherine did her PhD at the LIPM in Jean Dénarié’s lab where she studied the genetic basis of Sinorhizobium meliloti plant compound catabolism. She was recruited as a scientist at IRD (Research Institute for Development) and spent 7 years in Dakar, Western Africa. Her work focussed on rhizobia, nodulation genes and Nod factor diversity (association studies). She then moved back to France, in Montpellier (LSTM) where she discovered β-proteobacteria able to nodulate legumes (now called β-rhizobia). Catherine re-joined the LIPM in 2003 as an INRA member, where she set up her own research group that she co-directed with Jacques Batut during several years. She selected Cupriavidus taiwanensis as a β-rhizobium model and completely sequenced its genome in collaboration with the Genoscope. More recently, she has launched a real-time evolution experiment aiming at evolving a non-symbiotic bacterium, the plant pathogen Ralstonia solanacearum, into a legume symbiont.


Philippe Remigi, CRCN CNRS

Philippe Remigi

Philippe did his PhD at LIPM under the supervision of N. Peeters (S. Genin’s team) on the functional and evolutionary characterisation of a family of type III effectors from the plant pathogenic bacterium Ralstonia solanacearum. He then moved to C. Masson-Boivin’s group for a first post-doc to investigate transient hypermutagenesis occurring during the experimental evolution of R. solanacearum into a legume symbiont. Next, he went to New-Zealand for a second post-doc in P. Rainey’s team (Massey University, Auckland) to study an experimentally evolved epigenetic switch and the evolutionary transition to multicellularity using Pseudomonas fluorescens as a model bacterium. Philippe was hired in 2019 as researcher in the C. Masson-Boivin-D. Capela’s team to analyse the transcriptional responses of Mimosa pudica to bacterial adaptation to endosymbiosis and study the evolutionary dynamics of bacterial populations during the experimental evolution of R. solanacearum into legume symbiont.


Saïda Mouffok, IE INRAE

Saïda holds a PhD in Molecular Genetics obtained at the University of Toulouse (LBME) in 2014. Saïda brings her expertise in protein biochemistry to  the AOI project: protein tagging, purification of native and tagged proteins of bacterial or plant origin, sample preparation for proteomics, identification of interacting protein partners (pull down  assays, bacterial two-hybrid).


Anne-Claire Cazalé-Noël, IR INRAE

Anne-Claire Cazalé-Noël, IR INRAE

Anne-Claire has studied signalisation (reactive oxygen species production and protein kinases) in plants in response to abiotic stress during her PhD at the ISV (CNRS, Gif-sur-Yvette, France) and during her post-doc at the MPIZ (Koeln, Germany). She analyzed the heavy metal tolerance during two post-docs at the Leibniz-IPB (Halle/Saale, Germany) and at CEA Cadarache (France). She joined the LIPM in 2007 to contribute to the characterization of the type III effectors from Ralstonia solanacearum in the team of Stéphane Genin. From 2015 to 2020, she worked in the team of Claude Bruand to participate in the elucidation of the roles of nitric oxide (NO) in the Medicago truncatula-Sinorhizobium meliloti symbiotic interaction. More specifically, she studied the protein post-translational modifications induced by NO. Since 2020, Anne-Claire joined the team of Delphine Capela to analyze transcriptomic modifications in the Mimosa pudica legume in response to the progressive adaptation of experimentally evolved symbionts.


Ginaini Grazielli Doin de Moura, PHD student

Ginaini Grazielli Doin de Moura

Ginaini Grazielli Doin de Moura obtained a Master degree in agricultural microbiology from the Federal University of Lavras in Brazil. During her Master, she worked on the selection and characterization of plant growth-promoting bacteria on strawberry plants. In 2019, she obtained a grant from the doctoral school SEVAB to perform a thesis under the co-direction of D. Capela and P. Remigi au LIPM. Her research project concerns the analysis of the genetic bases of bacterial adaptation during experimental evolution of a plant pathogen into Mimosa pudica legume symbionts.