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Alice Marmugi et al. (2011) Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver. Hepatology.

The Integrative Toxicology and Metabolism research team, investigated the effects on the liver resulting from prolonged exposure to low doses of bisphenol A (up to 10 times lower than the acceptable daily intake). The team has shown that low doses had a greater impact than higher doses on the activity of a set of genes involved in the production of lipids. It also showed that these effects, focusing on the level of gene expression, resulted in an increased storage of fat in the liver of mice exposed to low doses of bisphenol A. The accumulation of excessive fat in the liver, or steatosis, is not by itself of major gravity, but it has the potential to foster the emergence of other metabolic and/or tissue changes leading to more serious conditions such as NASH (non-alcoholic steato-hepatitis) or type 2 diabetes. This study is therefore in a line of work that lead to take more into account the metabolic disturbances in the assessment of risk associated with exposure to bisphenol A.