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INRAE

24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

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The team

Head of the team: Olivier PUEL

The Biosynthesis & Toxicity of Mycotoxins team
Equipe_2018_Site

Team Members

First Name

Family Name

Position

Groupe

Olivier

PUEL

IR1 INRAE, PhD, HDR

Myco

Isabelle

OSWALD

DREX INRAE, Agr. Eng, PhD, HDR

Tox

Laura

SOLER-VASCO

CRCN INRAE, PhD

Tox

Philippe

PINTON

IR INRAE, PhD

Tox

Sophie

LORBER

CRHC INRAE, PhD, HDR

Myco

Thierry

GAUTHIER

IR INRAE, PhD

Tox

Sylvie

PUEL

TREX INRAE

Tox

Delphine

PAYROS

Post-doctoral fellow 2020-2021

Tox

Chrystian

ZETINA

Post-doctoral fellow 2021-2023

Myco

Marion

GAROFALO

PhD student 2019-2022

Tox

Nadia

TAHTAH

PhD student 2018-2021

Myco

Carine

AYOUBI

PhD student 2019-2022

Tox

Bernadette

WILLOQUET

PhD student 2021-2024

Tox

Permanent staff
OPUEL

Olivier PUEL, PhD, HDR
Research engineer
Team manager
Phone: + 33 582 06 63 36
E-mail: olivier.puel[at]inrae.fr ([at] = @)

  • Olivier Puel is the team manager of the bioToMyc team since September 1, 2021. Since his recruitment by INRA, Olivier Puel studies molecular basis of mycotoxins production in Aspergillus, Penicillium and Fusarium species. The main research topics are elucidation of mycotoxin biosynthesis pathways and chemical and biological characterizations of the different toxins (including new toxins) produced by fungi.He was involved in several national projects such as ANR project ISNATOX 2005-2007 « Production de standards internes de toxines d’origine naturelle uniformément enrichis par des isotopes stables ». In this last project; he was involved in the development of methodology of stable isotopes labelled toxin production, and more particularly in the fungi cultures and in the toxins production and purification.He is also the Coordinator of a recent AFSSET project (2007-09) on “Assessment of Aspergillus fumigatus toxins toxicity”.
Photo_Isabelle_2

Isabelle OSWALD, Agr. Eng., PhD, HDR
Research director
Head of the Joint Research Unit TOXALIM
Phone: + 33 582 06 63 66
E-mail: isabelle.oswald[at]inrae.fr ([at] = @)

  • Isabelle Oswald is the head of Toxalim since 2018 and was the head of the BioToMyc team from 2002 to 2021. She focuses her work on the effect of mycotoxin on pigs with particular emphasis on the effect of these toxins on the immune response and on the intestine. Isabelle Oswald belongs to several expert committee at the national and international level (ANSES, expert group on “Residues, physical and chemical contaminants”; ILSI, expert group on “masked mycotoxins”, EFSA, working groups on “mycotoxin detoxifying agents” and working group on “Fusarium toxins”). She is also in the editorial board of several journals (Veterinary Immunology and Immunopathology, Journal of Animal Sciences, The Open Veterinary Science Journal et ISRN Veterinary Science).
Laura SV 2

Laura SOLER-VASCO, DMV, PhD
Research scientist
Phone: + 33 582 06 64 03
E-mail: laura.soler-vasco[at]inrae.fr ([at] = @)

  • After a PhD in veterinary medicine in Spain (Murcia University), Laura worked as a post-doctoral fellow in Spain (Murcia University), Belgium (KU Leuven) and France (INRA Val-de–Loire, Tours). She has been recruited at INRA in 2016.  She is interested in the study of the intestinal physiopathology in porks, the development of new animal diagnostics and proteomics.
Sophie_2016

Sophie LORBER, PhD, HDR
Research scientist
Phone: +33 582 06 63 58
E-mail: sophie.lorber[at]inrae.fr ([at]=@)

  • Sophie joined the team in january 2016. After a PhD in plant biochemistry and a post-doctoral fellow at BASF (Germany), Sophie has been recruited at INRA in 1995. Her researches were focused on glutathione transferases and the chemical fate of pesticides and other organic contaminants in plants. She works on patulin biosynthesis and its regulation.
PPinton

Philippe PINTON, Phd
Engineer
Phone: +33 582 06 63 74
E-mail: philippe.pinton[at]inrae.fr ([at] = @)

  • Philippe first worked at CEA and was recruited at INRA in 1993 in the Laboratory of Cellular Genetic. He joined the unit in 2001. He contributes to the development of several methodologies used in the team including experimental approaches on animal models and cell culture of intestinal explants. He also leads a research project on the effects of deoxynivalenol and chemical derivatives on the intestinal tissue.
Thierry Gauthier

Thierry GAUTHIER, Phd
Engineer
Phone: +33 582 06 63 81
E-mail: thierry.gauthier[at]inrae.fr ([at] = @)

  • After an engineering degree in Biotechnology (INSA Toulouse, 1986) and a doctorate in cell physiology (University of Toulouse, 1989), Thierry Gauthier first worked as a researcher in a French start-up developing immunosuppressive drugs. He joined INRA in 1993 within the economic valuation service and then as deputy head of the Animal Health department responsible of partnership with industry. Since 2009, he is a research engineer at TOXALIM where he has conducted toxicology studies relating to mycotoxins, fungicides and 4-hydroxynonenal (produced from lipid peroxidation) using in vitro approaches. His work focuses on understanding the mechanisms of toxicity at cellular and molecular levels. Since January 2022, he belongs to the team “Biosynthesis and Toxicity of Mycotoxins” where he is involved in the study of the cellular response following exposure to mycotoxins.
Sylvie

Sylvie PUEL
Research technician
Phone: +33 582 06 64 62
E-mail: sylvie.puel[at]inrae.fr ([at] = @)

  • Sylvie joined the INRA Center of Toulouse in 2005 where she works as a technician in analytical chemistry. She has developed a solid technical expertise in quantification of xenobiotics and endogenous compounds (method development and validation) by liquid chromatography paired with UV, fluo, or mass spectrometry detection. She is also involved in missions of general interest (quality cell, staff representative, member of the unit board, member of the ADAS management board). In 2017, Sylvie joined the team.

Temporary Staff

Inconnue

Delphine PAYROS
Post-doctoral fellow 2020-2021
E-mail : delphine.payros[at]inrae.fr ([at] = @)

  • Research topic: Impact of a mycotoxin on genotoxicity.
C ZETINA-E5

Chrystian ZETINA
Post-doctoral fellow 2021-2023
E-mail: Chrystian-Del-Carmen.Zetina-Serrano[at]inrae.fr ([at]=@)

  • Research topics: Use of natural compounds to inhibit the production of mycotoxins by toxigenic moulds: field and silage applications.
Marion Garofalo

Marion GAROFALO
PhD 2019-2022
E-mail: marion.garofalo[at]inrae.com ([at] = @)

  • Thesis title: Impact of a mycotoxin on genotoxicity.
Nadia

Nadia TAHTAH
PhD 2018-2022
E-mail: nadia.tahtah[at]inrae.fr ([at] = @)

  • Thesis title: Impact of the velvet complex on the seconday metabolism of Penicillium expansum.
C AYOUBI-E5

Carine AYOUBI
PhD 2019-2022
E-mail: carine.al-ayoubi[at]inrae.fr  ([at] = @)

  • Thesis title: Versicolorin A: assessment of its toxicity by OMICS approach.
Bernadette Willoquet

Bernadette WILLOQUET
PhD 2021-2024
bernadette.willoquet[at]inrae.fr  ([at] = @)

  • Thesis title: Interaction between two mycotoxins, aflatoxin B1 and deoxynivalenol: effect on cytochrome P450 enzymes.
Former team members
Joelle Laffitte

Joëlle LAFFITTE
Research technician

  • Joelle has worked in the INRA Reseach Center of Bordeaux from 1989 to 1997. She joined the Research Centre of Toulouse in 1997 where she worked as a technician. She has developed a solid technical expertise on the analysis of protein expression. She also performed many experimental protocols ranging from animal experiment to biochemical and cellular analysis. She was involved in several scientific projects while ensuring the team inventory management of consumables.
O ROCHER-E5

Ophélie ROCHER
IE 2018-2022

  • Ophélie joined the team in 2017, first for a master research project and after as an IE INRAE.
Alix

Alix PIERRON
Post-doctoral fellow 2019-2021

  • Research topics: Toxicity of deoxynivalenol and its derivatives in pig.
Jean-Denis-Bailly_small

Jean-Denis BAILLY
Professor - National Veterinary School of Toulouse

Christopher

Christopher HERNANDEZ
PhD 2018-2021
E-mail: hernandezhernandezchristopher[at]gmail.com ([at] = @)

  • Thesis title: Modulation of mycotoxinogenesis by natural extracts: identification of active compounds and characterization of their mechanism of action.
Anthony

Antony EL KHOURY
PhD 2018-2021

  • Thesis title: Role of polyphenols in mycotoxinogenesis: case of aflatoxin B1
T FERNANDES-E5

Thiago FERNANDES
Post-doctoral fellow 2020-2021

  • Research topics: Regulation of the metabolome in Aspergillus species by epigenetic regulators.
Tarek Lahjouji

Tarek LAHJOUJI
PhD 2017-2020

  • Thesis title: Effect of zearalenone, alone or as a mixture, on the intestine.
S WANG-E5

Shuai WANG
Post-doctoral fellow 2019-2020

  • Research topics: Modulation of the toxicity of fumonisin by lipids.
Imourane Alassane

Imourana ALASSANE-KPEMBI

  • Research topics: Transcriptomic profile of intestinal toxicity of mycotoxins.
MAnon Neves

Manon NEVES
AI 2016-2018

  • After a master research project focused on the effects of pesticides on hepatic cell metabolism, Manon joined the team in 2016. She works on the effects of mycotoxines in vivo and in vitro.
Chloe

Chloé TERCIOLO
Post-doctoral fellow 2017-2018

  • Research topics: Relation between DON and satiety hormones and also modulation of the toxicity of fumonisin by lipids.
Su_site_2016

Su LUO
PhD student 2016-2019

  • Research topics: ffects of cadmium and deoxynivalenol in mammals.
Abdullah

Abdullah KHOSHAL
PhD 2017-2020

  • Research topics: Effect of combined toxicity of emerging and regulated mycotoxins.
Joya

Joya MAKHLOUF
PhD student 2013-2019

  • : Characterization of the biodiversity of Aspergillus Flavi strain in libanese food products, by a molecular, metabolic and morphological approach.
Laura COSTES

Laura COSTES
PhD student 2014-2018

  • Research topics: Negative modulation of fungal toxinogenesis by natural compounds.
Christelle

Christelle EL HAJJ ASSAF
PhD student 2015-2018

  • Research topics: Regulation of the biosynthetic pathway of patuline and influence of processing factors in cloudy apple juice production.
Sylviane Bailly

Sylviane BAILLY, DMV
IE INP-ENVT
National Veterinary School of Toulouse

  • Sylviane joined the team in January 2012. After her training as veterinarian and some years of practical professional activity in the field, Sylviane created an analytical laboratory specializied in mycology food analysis. After seven years in business, her research interest motivated her to join a research team, first at ENVT then within Toxalim, Research Centre in Food Toxicology. Sylviane is a specialist in mycology (morphological identification of fungal species) and participated in all the work on the control of fungal toxin production.
Amaranta

Amaranta CARVAJAL-CAMPOS
PhD student 2014-2017

  • Research topics: Characterization of Aspergillus section Flavi: molecular markers as tools to unmask cryptic species.
Thanh 2016

Thanh-Huong LE
PhD student 2015-2018

  • Research topics: Toxicity of the mixture of two contaminants, cadmium and deoxynivalenol, on mammals.
Thais Hautbergue 2016

Thaïs HAUTBERGUE
PhD student 2014-2017

  • Research topics: Characterization of the secondary metabolome of Penicillium by isotopic labeling and mass spectrometry.
B ALEKSIC

Brankica ALEKSIC
Post-doctoral fellow 2016-2017
E-mail : baleksic[at]inra.fr  ([at] = @)

  • Research topics: Modulation of mycotoxin production by natural extracts, focused on aerosolization during the development of toxicogenic species and tool development of habitat monitoring.
Inconnue

Delphine PAYROS
Post-doctoral fellow 2016-2017

  • Research topics:Evaluation of the consequences of Fusarium toxins on rodent sensitivity to develop intestinal chronic inflammatory diseases.
Isaura Caceres

Isaura CACERES
PhD student 2013-2016

  • Research topics:Use of specific techniques of molecular biology to follow gene expression in order to elucidate mechanisms of action of natural products to suppress aflatoxine B1 production.
Selma

Selma SNINI
Post-Doctoral fellow 2016. PhD defended in 2014

  • Research topics: Characterization of the toxic effects of versicolorine.
Rhoda El Khoury

Rhoda EL KHOURY
PhD student 2013-2016

Research topics: Aflatoxin risk management, use of natural plant extracts.

leticia

Leticia MURATE
Post-doctoral fellow 2014-2015

  •  (i) Toxicity of deoxynivalenol,and its deepoxydated derivative; (ii) Toxicity of aflatoxine on pig intestine.
Photo P_ Goubeyre

Pascal GOURBEYRE
Post-doctoral fellow 2013-2015

  • Research topics: Expression of receptors for microbial components along the digestive tract of healthy pigs.
Inconnue

Sabria MIMOUN
Post-doctoral fellow 2013-2015

  • Research topics: Effects of a nutritional ingredient enriched in superoxide dismutase (SOD) on the pig immune response.
sophal

Sophal CHEAT
PhD student 2012-2015

  • Research topics: Individual and combined effects of the trichothecenes deoxynivalenol and nivalenol ex vivo and in vivo on pig intestinal mucosa.
Joanna Tannous

Joanna TANNOUS
PhD student 2011-2014

  • Research topics: Characterization of the regulation factor of the biosynthesis pathway of patulin.
Patricia Cano

Patricia CANO
Ph.D. Student 2010-2013

  • Research topics: Characterization of the metabolome of Fusarium graminearum: Detection and effects on the intestinal barrier.
Julie Seeboth

Julie SEEBOTH
PhD student 2010-2013

  • Research topics: Trichothecenes impact on mucosal immunity and use of Lactobacillus sobrius as microbiological control measure against these mycotoxins.
DSC_0419

Bertrand GRENIER
PhD student 2008-2011

  • Research topics: Effect in pigs of the exposure to a mycotoxin co-contaminated diet, and evaluation of control strategies.