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COMICS: Contaminants & Cellular Stress

COMICS: Contaminants &  Cellular Stress
photo equipe comics confocal_small

Scientific context

The links between the environment and the occurrence of chronic diseases are increasingly supported by epidemiological studies, particularly those related to the presence of contaminants in food. The mechanisms that underlie these deleterious effects on human health remain to be established, however, with the methodological constraints inherent to food toxicology: low doses, chronic exposures, mixtures, ADME of the digestive tract (absorption, distribution, metabolism, elimination and microbiota). Since genetic polymorphism affects the cellular response, we pay particular attention to the contribution of susceptibility genes involved in aging and carcinogenesis in response to contaminants.

Our approaches

Through mechanistic approaches developed in vitro, we determine how cells respond to exposure to contaminants by considering several parameters:

  •     Genetic susceptibility
  •     The involvement of G protein-coupled receptors (GPCRs)
  •     Activation of xenosensors

Cellular responses, having major roles in the toxic processes of contaminants, can be broken down as follows:

  •     Oxidative stress
  •     Genotoxic stress
  •     Metabolic stress
  •     Mitochondrial stress

See also

“Goals & Achievements” hComet

New video on Cost hComet now online, partially shot in Toxalim

Cost hComet “Goals & Achievements” Video
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Financial Support SOHO « SDHI-EcoHealth » Ecophyto2+-Agence Française pour la Biodiversité (2020-2023)

Impacts of SDHi fungicides on health and biodiversity:a toxicological and socioeconomic EcoHealth evaluation Coordinator : Laurence HUC
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Ecole Clinique de la Société Française de Nutrition « Polluants dans l’alimentation » (Septembre 2019, Paris)

Oral Presentation, Laurence Huc « manger (une pomme) est-il (encore) bon pour la santé ? »
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CYCLOPE Conference CEA-Saclay “Tous perturbés?” (Juillet 2019, Saclay)

Laurence HUC Presentation with Marie-Justine Guerquin, Jean-Baptiste Fini & Jérôme Santolini
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European Researchers’ Night

European Researchers’ Night (September 2019)

COMICS contributed to the success of the 2019 European Researchers’ Night "le fabuleux destin du goûter englouti"
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Muséum National d’Histoire Naturelle

Muséum National d’Histoire Naturelle, UMR 7221, Laboratoire Evolution des Régulations Endocriniennes (may 2019, Paris)

Laurence Huc Invited Conference “Food contaminants and environmental carcinogenesis: how can the newly identified mechanisms of toxicity refine...
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STSM (Short Time Scientific Mission) of Gunnar (Norwegian Institute of Public Health, Oslo)

Collaboration Gunnar BRUNBORG (Mars 2019, FabLab, Université Paul Sabatier, Toulouse)

STSM (Short Time Scientific Mission) of Gunnar (Norwegian Institute of Public Health, Oslo) in the COMICS team, european Cost action hComet
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Organisation : COMICS Team in collaboration with Bertrand POURRUT (ENSAT, Toulouse)

Cost hComet Working Groups Meetings (Mars 2019, Toulouse)

Organisation : COMICS Team in collaboration with Bertrand POURRUT (ENSAT, Toulouse)
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CECED (Club d'Etudes des Cellules Epithéliales Digestives) (Mars 2019, Toulouse)

CECED (Club d'Etudes des Cellules Epithéliales Digestives) (Mars 2019, Toulouse)

« Impact de contaminants alimentaires en fonction de la susceptibilité génétique au cancer colorectal »
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Film Scientifique Cost hComet

EU Cost Action : Scientific filming Cost hComet (Mars 2019, Toxalim)

Scientific team : Amaya AZQUETA, Sabine LANGIE, Gunnar BRUNBORG, Elisa BOUTET-ROBINET Cameraman : Tom ODYSSEY
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