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COMICS: Contaminants & Cellular Stress

COMICS: Contaminants &  Cellular Stress
photo equipe comics confocal_small

Scientific context

The links between the environment and the occurrence of chronic diseases are increasingly supported by epidemiological studies, particularly those related to the presence of contaminants in food. The mechanisms that underlie these deleterious effects on human health remain to be established, however, with the methodological constraints inherent to food toxicology: low doses, chronic exposures, mixtures, ADME of the digestive tract (absorption, distribution, metabolism, elimination and microbiota). Since genetic polymorphism affects the cellular response, we pay particular attention to the contribution of susceptibility genes involved in aging and carcinogenesis in response to contaminants.

Our approaches

Through mechanistic approaches developed in vitro, we determine how cells respond to exposure to contaminants by considering several parameters:

  •     Genetic susceptibility
  •     The involvement of G protein-coupled receptors (GPCRs)
  •     Activation of xenosensors

Cellular responses, having major roles in the toxic processes of contaminants, can be broken down as follows:

  •     Oxidative stress
  •     Genotoxic stress
  •     Metabolic stress
  •     Mitochondrial stress

See also

Symposium « Metabolism, Cancer and Beyond » Fondation Toulouse Cancer Santé (Février 2019)

Symposium « Metabolism, Cancer and Beyond » Fondation Toulouse Cancer Santé (Février 2019)

« Environmental cancer and metabolic reprogramming : new paradigm of carcinogenesis by food contaminants ? »
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Grant from Fondation ARC, Recherche Contre Le Cancer (Toxalim, Janvier 2019)

Grant from Fondation ARC, Recherche Contre Le Cancer (Toxalim, Janvier 2019)

EXPOTOX project "Antifungal inhibitors of succinate dehydrogenase and their impact on carcinogenesis", ARC Grant for 24 months.
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COMICS Team participation, workshop « The fabulous journey in my gut »

EuroScience Open Forum (ESOF, Juillet 2018, Festival Science in the City, Toulouse)

COMICS Team participation, workshop « The fabulous journey in my gut »
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