Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free:

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site:, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Google Analytics

Targeted advertising cookies


The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at or by post at:

24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo envt small Logo INP-EI Purpan Logo UPS-Tlse3

Home page

Zone de texte éditable et éditée et rééditée


Our publications


• Minimum Information for Reporting on the Comet Assay (MIRCA): recommendations for describing comet assay prodecures and results
Møller P*, Azqueta A, Boutet-Robinet E, Koppen G, Bonassi S et al.
Nature Protocols (in press)

Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells.
Bénit P, Kahn A, Chretien D, Bortoli S, Huc L, Schiff M, Gimenez-Roqueplo AP, Favier J, Gressens P, Rak M, Rustin P.
PLoS One. 2019 Nov 7;14(11):e0224132. doi: 10.1371/journal.pone.0224132.

Versicolorin A, a precursor in aflatoxins biosynthesis, is a food contaminant toxic for human intestinal cells.
Gauthier T, Duarte-Hospital C, Vignard J, Boutet-Robinet E, Sulyok M, Snini SP, Alassane-Kpembi I, Lippi Y, Puel S, Oswald IP, Puel O.
Environ Int. 2020 Apr;137:105568. doi: 10.1016/j.envint.2020.105568.

Application of the comet assay in human biomonitoring: An hCOMET perspective.
Azqueta A, Ladeira C, Giovannelli L, Boutet-Robinet E, Bonassi S et al.
Mutat Res. 2020 Jan-Mar;783:108288. doi: 10.1016/j.mrrev.2019.108288.

• 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
Fersing C, Boudot C, Castera-Ducros C, Pinault E, Hutter S, Paoli-Lombardo R, Primas N, Pedron J, Seguy L, Bourgeade-Delmas S, Sournia-Saquet A, Stigliani JL, Brossas JY, Paris L, Valentin A, Wyllie S, Fairlamb AH, Boutet-Robinet É et al.
Eur J Med Chem. 2020 Sep 15;202:112558. doi: 10.1016/j.ejmech.2020.112558.

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Pedron J, Boudot C, Brossas JY, Pinault E, Bourgeade-Delmas S, Sournia-Saquet A, Boutet-Robinet E et al.
ACS Med Chem Lett. 2020 Feb 6;11(4):464-472. doi: 10.1021/acsmedchemlett.9b00566.


Disturbances in H+ dynamics during environmental carcinogenesis.
Lagadic-Gossmann D, Hardonnière K, Mograbi B, Sergent O, Huc L.
Biochimie. 2019 Aug;163:171-183. doi: 10.1016/j.biochi.2019.06.013

Xenobiotics and their impact on metabolic diseases
Duarte-Hospital C, Huc L, Bortoli S, Coumoul X.
Cahiers de Nutrition et de Diététique. 2019 Oct;54 (5):286-293

Technical recommendations to perform the alkaline standard and enzyme-modified comet assay in human biomonitoring studies.
Azqueta A, Muruzabal D, Boutet-Robinet E, Milic M, Dusinka M, Brunborg G,  Moller P, Collins A.
Mutation Research-Genetic Toxicology and environmental mutagenesis. 2019 Jul;843:24-32. doi: 10.1016/j.mrgentox.2019.04.007

DNA repair as a human biomonitoring tool; comet assay approaches
Azqueta A, Langie SAS, Boutet-Robinet E, Duthie S, Ladeira C, Møller P, Collins A, Godschalk RWL on behalf of Working Group 5 of the hCOMET project (CA15132)
Mutation Research/Reviews in Mutation Research 2019

Haem iron reshapes colonic luminal environment: impact on mucosal homeostasis and microbiome through aldehyde formation.
Martin OCB, Olier M, Ellero-Simatos S, Naud N., Dupuy J, Huc L, Taché S, Graillot V, Levêque M, Bézirard V, Héliès-Toussaint C, Estrada FBY, Tondereau V, Lippi Y, Naylies C, Peyriga L, Canlet C, Davila AM, Blachier F, Ferrier L, Boutet-Robinet E, Guéraud F, Théodorou V, Pierre FHF.
Microbiome. 2019 May 6;7(1):72. doi: 10.1186/s40168-019-0685-7.

Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells.
Fernandez-Vidal A, Arnaud LC, Maumus M, Chevalier M, Mirey G, Salles B, Vignard J, Boutet-Robinet E
Environ Mol Mutagen. 2019 Apr;60(3):286-297. doi: 10.1002/em.22268. Epub 2018 Dec 19.


•  Exposure to the fungicide captan induces DNA base alterations and replicative stress in mammalian cells.
Fernandez-Vidal A, Arnaud LC, Maumus M, Chevalier M, Mirey G, Salles B, Vignard J, Boutet-Robinet E
Environ Mol Mutagen. (in press).
•  Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene.
Liamin M, Le Mentec H, Evrard B, Huc L, Chalmel F, Boutet-Robinet E, Le Ferrec E, Sparfel L.
Int. J. Mol. Sci. 2018, 19, 3626.
• Validation of Gelbond® high-throughput alkaline and Fpg-modified comet assay using a linear mixed model.
Perdry H, Gutzhow KB, Chevalier M, Huc L, Brunborg G, Boutet-Robinet E
Environ Mol Mutagen. 2018 Aug;59(7):595-602. doi: 10.1002/em.22204. Epub 2018 Aug 9
•  DNA damage response upon environmental contaminants: An exhausting work for genomic integrity.
Boutet-Robinet E, Bortoli S, Huc L.
Current Opinion in Toxicology 2018 Vol 8:28-33 doi: 10.1016/j.cotox.2017.12.002
•  Nrf2 and AhR in metabolic reprogramming after contaminant exposure.
Bortoli S, Boutet-Robinet E, Lagadic-Gossmann D, Huc L.
Current Opinion in Toxicology2018  Vol 8:34-41 doi: 10.1016/j.cotox.2017.12.001


•   Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S. Sci Rep. 2017 Jul 31;7(1):6945. doi: 10.1038/s41598-017-07006-0.
PMID:    28761044
•    Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.
Hardonnière K, Fernier M, Gallais I, Mograbi B, Podechard N, Le Ferrec E, Grova N, Appenzeller B, Burel A, Chevanne M, Sergent O, Huc L, Bortoli S, Lagadic-Gossmann D.
Sci Rep. 2017 Mar 15;7(1):195. doi: 10.1038/s41598-017-00269-7.
PMID:    28298645
•    Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism.
Hardonnière K, Huc L, Sergent O, Holme JA, Lagadic-Gossmann D.
Semin Cancer Biol. 2017 Apr;43:49-65. doi: 10.1016/j.semcancer.2017.01.001. Epub 2017 Jan 11. Review.
PMID:    28088583
•    A French crop-exposure matrix for use in epidemiological studies on pesticides: PESTIMAT.
Baldi I, Carles C, Blanc-Lapierre A, Fabbro-Peray P, Druet-Cabanac M, Boutet-Robinet E, Soulat JM, Bouvier G, Lebailly P; PESTIMAT Group.
J Expo Sci Environ Epidemiol. 2017 Jan;27(1):56-63. doi: 10.1038/jes.2015.72. Epub 2015 Dec 23.
PMID:    26696463
•    Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes.
Liamin M, Boutet-Robinet E, Jamin EL, Fernier M, Khoury L, Kopp B, Le Ferrec E, Vignard J, Audebert M, Sparfel L.
Biochem Pharmacol. 2017 Aug 1;137:113-124. doi: 10.1016/j.bcp.2017.04.025. Epub 2017 Apr 29.
PMID:    28461126
•    Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon.
Bettini S, Boutet-Robinet E, Cartier C, Coméra C, Gaultier E, Dupuy J, Naud N, Taché S, Grysan P, Reguer S, Thieriet N, Réfrégiers M, Thiaudière D, Cravedi JP, Carrière M, Audinot JN, Pierre FH, Guzylack-Piriou L, Houdeau E.
Sci Rep. 2017 Jan 20;7:40373. doi: 10.1038/srep40373.
PMID:    28106049


•    The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival.
Hardonnière K, Saunier E, Lemarié A, Fernier M, Gallais I, Héliès-Toussaint C, Mograbi B, Antonio S, Bénit P, Rustin P, Janin M, Habarou F, Ottolenghi C, Lavault MT, Benelli C, Sergent O, Huc L*, Bortoli S*, Lagadic-Gossmann D*.
Sci Rep. 2016 Aug 4;6:30776. doi: 10.1038/srep30776.
PMID:    27488617
•    Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis.
Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J.
Front Cell Infect Microbiol. 2016 Mar 23;6:34. doi: 10.3389/fcimb.2016.00034. eCollection 2016.
PMID:    27047802
•    Red meat and colorectal cancer: Nrf2-dependent antioxidant response contributes to the resistance of preneoplastic colon cells to fecal water of hemoglobin- and beef-fed rats.
Surya R, Héliès-Toussaint C, Martin OC, Gauthier T, Guéraud F, Taché S, Naud N, Jouanin I, Chantelauze C, Durand D, Joly C, Pujos-Guillot E, Pierre FH, Huc L.
Carcinogenesis. 2016 Jun;37(6):635-645. doi: 10.1093/carcin/bgw035. Epub 2016 Mar 18.
•    Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.
Bezine E, Malaisé Y, Loeuillet A, Chevalier M, Boutet-Robinet E, Salles B, Mirey G, Vignard J.
Sci Rep. 2016 Oct 24;6:36022. doi: 10.1038/srep36022.
PMID:    27775089


•    Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.
Hardonnière K, Huc L, Podechard N, Fernier M, Tekpli X, Gallais I, Sergent O, Lagadic-Gossmann D.
Toxicol In Vitro. 2015 Oct;29(7):1597-608. doi: 10.1016/j.tiv.2015.06.010. Epub 2015 Jun 15.
PMID:    26086121
•    DNA damage in B and T lymphocytes of farmers during one pesticide spraying season.
Lebailly P, Mirey G, Herin F, Lecluse Y, Salles B, Boutet-Robinet E*.
Int Arch Occup Environ Health. 2015 Oct;88(7):963-72. doi: 10.1007/s00420-015-1024-3. Epub 2015 Feb 3.
PMID:    25647545
•    DNA damage and oxidative stress induced at low doses by the fungicide hexachlorobenzene in human intestinal Caco-2 cells.
Chalouati H, Boutet E, Metais B, Fouche E, Ben Sâad MM, Gamet-Payrastre L.
Toxicol Mech Methods. 2015;25(6):448-58. doi: 10.3109/15376516.2015.1082000. Epub 2015 Sep 12.
PMID:    26365763


•    Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.
Marmugi A, Lasserre F, Beuzelin D, Ducheix S, Huc L, Polizzi A, Chetivaux M, Pineau T, Martin P, Guillou H, Mselli-Lakhal L.
Toxicology. 2014 Nov 5;325:133-43. doi: 10.1016/j.tox.2014.08.006. Epub 2014 Aug 26.
•    Cell cycle modulation by Marek's disease virus: the tegument protein VP22 triggers S-phase arrest and DNA damage in proliferating cells.
Trapp-Fragnet L, Bencherit D, Chabanne-Vautherot D, Le Vern Y, Remy S, Boutet-Robinet E, Mirey G, Vautherot JF, Denesvre C.
PLoS One. 2014 Jun 19;9(6):e100004. doi: 10.1371/journal.pone.0100004. eCollection 2014.
PMID:    24945933


•    Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance.
Dalleau S, Baradat M, Guéraud F, Huc L.
Cell Death Differ. 2013 Dec;20(12):1615-30. doi: 10.1038/cdd.2013.138. Epub 2013 Oct 4. Review.
PMID:    24096871
•    Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3- co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.
Garciarena CD, Ma YL, Swietach P, Huc L, Vaughan-Jones RD.
J Physiol. 2013 May 1;591(9):2287-306. doi: 10.1113/jphysiol.2012.249664. Epub 2013 Feb 18.
•    A switch of G protein-coupled receptor binding preference from phosphoinositide 3-kinase (PI3K)-p85 to filamin A negatively controls the PI3K pathway.
Najib S, Saint-Laurent N, Estève JP, Schulz S, Boutet-Robinet E, Fourmy D, Lättig J, Mollereau C, Pyronnet S, Susini C, Bousquet C.
Mol Cell Biol. 2012 Mar;32(5):1004-16. doi: 10.1128/MCB.06252-11. Epub 2011 Dec 27.
PMID:    22203038
•    From single-strand breaks to double-strand breaks during S-phase: a new mode of action of the Escherichia coli Cytolethal Distending Toxin.
Fedor Y, Vignard J, Nicolau-Travers ML, Boutet-Robinet E, Watrin C, Salles B, Mirey G.
Cell Microbiol. 2013 Jan;15(1):1-15. doi: 10.1111/cmi.12028. Epub 2012 Oct 9.
PMID:    22978660
•    Neutral Comet Assay
Boutet-Robinet E*, Trouche D, Canitrot Y. Bioprotocol. Vol 3, Iss 18, September 20, 2013


•    Identification of the F1-ATPase at the cell surface of colonic epithelial cells: role in mediating cell proliferation.
Kowalski-Chauvel A, Najib S, Tikhonova IG, Huc L, Lopez F, Martinez LO, Cohen-Jonathan-Moyal E, Ferrand A, Seva C.
J Biol Chem. 2012 Nov 30;287(49):41458-68. doi: 10.1074/jbc.M112.382465. Epub 2012 Oct 10.
PMID:    23055519
•    NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function.
Tekpli X, Huc L, Sergent O, Dendelé B, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D.
Cell Physiol Biochem. 2012;29(5-6):657-66. doi: 10.1159/000171027. Epub 2012 May 11.
PMID:    22613966
•    The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks.
Courilleau C, Chailleux C, Jauneau A, Grimal F, Briois S, Boutet-Robinet E, Boudsocq F, Trouche D, Canitrot Y.
J Cell Biol. 2012 Dec 24;199(7):1067-81. doi: 10.1083/jcb.201205059.
PMID:    23266955
•    Low concentrations of bisphenol A induce lipid accumulation mediated by the production of reactive oxygen species in the mitochondria of HepG2 cells.
Huc L, Lemarié A, Guéraud F, Héliès-Toussaint C.
Toxicol In Vitro. 2012 Aug;26(5):709-17. doi: 10.1016/j.tiv.2012.03.017. Epub 2012 Apr 10.
•    Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.
Dendelé B, Tekpli X, Sergent O, Dimanche-Boitrel MT, Holme JA, Huc L, Lagadic-Gossmann D.
Toxicol In Vitro. 2012 Feb;26(1):94-101. doi: 10.1016/j.tiv.2011.11.001. Epub 2011 Nov 12.
PMID:    22100782


•    4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
Baradat M, Jouanin I, Dalleau S, Taché S, Gieules M, Debrauwer L, Canlet C, Huc L, Dupuy J, Pierre FH, Guéraud F.
Chem Res Toxicol. 2011 Nov 21;24(11):1984-93. doi: 10.1021/tx2003036. Epub 2011 Oct 19.
PMID:    21967605
•    Thyroid function tests in persons with occupational exposure to fipronil.
Herin F, Boutet-Robinet E, Levant A, Dulaurent S, Manika M, Galatry-Bouju F, Caron P, Soulat JM.
Thyroid. 2011 Jul;21(7):701-6. doi: 10.1089/thy.2010.0449. Epub 2011 May 26. Erratum in: Thyroid. 2011 Aug;21(8):939.
PMID:    21615307
•    Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction.
Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S.
Cell Death Differ. 2011 Feb;18(2):338-49. doi: 10.1038/cdd.2010.93. Epub 2010 Aug 13.
PMID:    20706275


•    Chemistry and biochemistry of lipid peroxidation products.
Guéraud F, Atalay M, Bresgen N, Cipak A, Eckl PM, Huc L, Jouanin I, Siems W, Uchida K.
Free Radic Res. 2010 Oct;44(10):1098-124. doi: 10.3109/10715762.2010.498477. Review.
PMID:    20836659
•    Use of reconstituted metabolic networks to assist in metabolomic data visualization and mining.
Jourdan F, Cottret L, Huc L, Wildridge D, Scheltema R, Hillenweck A, Barrett MP, Zalko D, Watson DG, Debrauwer L.
Metabolomics. 2010 Jun;6(2):312-321. Epub 2010 Jan 6.
PMID:    20526351
•    Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.
Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D.
Toxicol Appl Pharmacol. 2010 Feb 15;243(1):68-76. doi: 10.1016/j.taap.2009.11.014. Epub 2009 Nov 17.
PMID:    19931295


•    Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.
Lacroix J, Poët M, Huc L, Morello V, Djerbi N, Ragno M, Rissel M, Tekpli X, Gounon P, Lagadic-Gossmann D, Counillon L.
Biochemistry. 2008 Dec 23;47(51):13674-85. doi: 10.1021/bi801368n.
PMID:    19035652
•    Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.
Cussac D, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Martel JC, Danty N, Rauly-Lestienne I.
Eur J Pharmacol. 2008 Oct 10;594(1-3):32-8. doi: 10.1016/j.ejphar.2008.07.040. Epub 2008 Jul 30.
PMID:    18703043
•    Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains.
Tekpli X, Huc L, Lacroix J, Rissel M, Poët M, Noël J, Dimanche-Boitrel MT, Counillon L, Lagadic-Gossmann D.
J Cell Physiol. 2008 Jul;216(1):207-20. doi: 10.1002/jcp.21395.
•    A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.
Gorria M, Tekpli X, Rissel M, Sergent O, Huc L, Landvik N, Fardel O, Dimanche-Boitrel MT, Holme JA, Lagadic-Gossmann D.
Toxicol Appl Pharmacol. 2008 Apr 15;228(2):212-24. doi: 10.1016/j.taap.2007.12.021. Epub 2008 Jan 3.
PMID:    18255115


•    c-Jun NH2-terminal kinase-related Na+/H+ exchanger isoform 1 activation controls hexokinase II expression in benzo(a)pyrene-induced apoptosis.
Huc L, Tekpli X, Holme JA, Rissel M, Solhaug A, Gardyn C, Le Moigne G, Gorria M, Dimanche-Boitrel MT, Lagadic-Gossmann D.
Cancer Res. 2007 Feb 15;67(4):1696-705.
PMID:    17308111
•    Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.
Holme JA, Gorria M, Arlt VM, Ovrebø S, Solhaug A, Tekpli X, Landvik NE, Huc L, Fardel O, Lagadic-Gossmann D.
Chem Biol Interact. 2007 Apr 5;167(1):41-55. Epub 2007 Jan 17.
PMID:    17289009
•    TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.
Meurette O, Rebillard A, Huc L, Le Moigne G, Merino D, Micheau O, Lagadic-Gossmann D, Dimanche-Boitrel MT.
Cancer Res. 2007 Jan 1;67(1):218-26.
•    Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties.
Rauly-Lestienne I, Boutet-Robinet E, Ailhaud MC, Newman-Tancredi A, Cussac D.
Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):93-105. Epub 2007 Sep 5.
PMID:    17786406


•    Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol.
Gorria M, Tekpli X, Sergent O, Huc L, Gaboriau F, Rissel M, Chevanne M, Dimanche-Boitrel MT, Lagadic-Gossmann D.
Ann N Y Acad Sci. 2006 Dec;1090:108-12.
PMID:    17384252
•    Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport.
Gorria M, Huc L, Sergent O, Rebillard A, Gaboriau F, Dimanche-Boitrel MT, Lagadic-Gossmann D.
Biochem Pharmacol. 2006 Nov 15;72(10):1343-53. Epub 2006 Sep 7.
PMID:    16962073
•    Multiple apoptotic pathways induced by p53-dependent acidification in benzo[a]pyrene-exposed hepatic F258 cells.
Huc L, Rissel M, Solhaug A, Tekpli X, Gorria M, Torriglia A, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D.
J Cell Physiol. 2006 Sep;208(3):527-37.
PMID:    16688778


•    TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.
Meurette O, Huc L, Rebillard A, Le Moigne G, Lagadic-Gossmann D, Dimanche-Boitrel MT.
Ann N Y Acad Sci. 2005 Nov;1056:379-87.
PMID:    16387703
•    Role for membrane fluidity in ethanol-induced oxidative stress of primary rat hepatocytes.
Sergent O, Pereira M, Belhomme C, Chevanne M, Huc L, Lagadic-Gossmann D.
J Pharmacol Exp Ther. 2005 Apr;313(1):104-11. Epub 2005 Jan 5.
PMID:    15634942


•    Alterations of intracellular pH homeostasis in apoptosis: origins and roles.
Lagadic-Gossmann D, Huc L, Lecureur V.
Cell Death Differ. 2004 Sep;11(9):953-61. Review.
•    Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.
Sparfel L, Huc L, Le Vee M, Desille M, Lagadic-Gossmann D, Fardel O.
Biochem Pharmacol. 2004 May 1;67(9):1711-9.
•    Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.
Huc L, Sparfel L, Rissel M, Dimanche-Boitrel MT, Guillouzo A, Fardel O, Lagadic-Gossmann D.
FASEB J. 2004 Feb;18(2):344-6. Epub 2003 Dec 4.
PMID:    14656999


•    Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.
Huc L, Gilot D, Gardyn C, Rissel M, Dimanche-Boitrel MT, Guillouzo A, Fardel O, Lagadic-Gossmann D.
Ann N Y Acad Sci. 2003 Dec;1010:167-70.
PMID:    15033714
•    Endogenous RGS proteins facilitate dopamine D(2S) receptor coupling to G(alphao) proteins and Ca2+ responses in CHO-K1 cells.
Boutet-Robinet EA, Finana F, Wurch T, Pauwels PJ, De Vries L.
FEBS Lett. 2003 Jan 2;533(1-3):67-71.
PMID:    12505161
•    Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs.
Wurch T, Boutet-Robinet EA, Palmier C, Colpaert FC, Pauwels PJ.
J Pharmacol Exp Ther. 2003 Jan;304(1):380-90.
PMID:    12490615


•    Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.
Sparfel L, Loewert M, Huc L, Payen L, Guillouzo A, Lagadic-Gossmann D, Fardel O.
Toxicol Lett. 2002 Mar 28;129(3):245-54.
PMID:    11888708
•   Chronic treatment with certain antipsychotic drugs preserves upregulation of regulator of G-protein signalling 2 mRNA in rat striatum as opposed to c-fos mRNA.
Robinet EA, Geurts M, Maloteaux JM, Pauwels
Neurosci Lett. 2001 Jul 6;307(1):45-8.
PMID:    11516571
•  Different regulation of RGS2 mRNA by haloperidol and clozapine.
Robinet EA, Wurch T, Pauwels PJ.
Neuroreport. 2001 Jun 13;12(8):1731-5.
PMID:   11409749

See also