Know more

Our use of cookies

Cookies are a set of data stored on a user’s device when the user browses a web site. The data is in a file containing an ID number, the name of the server which deposited it and, in some cases, an expiry date. We use cookies to record information about your visit, language of preference, and other parameters on the site in order to optimise your next visit and make the site even more useful to you.

To improve your experience, we use cookies to store certain browsing information and provide secure navigation, and to collect statistics with a view to improve the site’s features. For a complete list of the cookies we use, download “Ghostery”, a free plug-in for browsers which can detect, and, in some cases, block cookies.

Ghostery is available here for free: https://www.ghostery.com/fr/products/

You can also visit the CNIL web site for instructions on how to configure your browser to manage cookie storage on your device.

In the case of third-party advertising cookies, you can also visit the following site: http://www.youronlinechoices.com/fr/controler-ses-cookies/, offered by digital advertising professionals within the European Digital Advertising Alliance (EDAA). From the site, you can deny or accept the cookies used by advertising professionals who are members.

It is also possible to block certain third-party cookies directly via publishers:

Cookie type

Means of blocking

Analytical and performance cookies

Realytics
Google Analytics
Spoteffects
Optimizely

Targeted advertising cookies

DoubleClick
Mediarithmics

The following types of cookies may be used on our websites:

Mandatory cookies

Functional cookies

Social media and advertising cookies

These cookies are needed to ensure the proper functioning of the site and cannot be disabled. They help ensure a secure connection and the basic availability of our website.

These cookies allow us to analyse site use in order to measure and optimise performance. They allow us to store your sign-in information and display the different components of our website in a more coherent way.

These cookies are used by advertising agencies such as Google and by social media sites such as LinkedIn and Facebook. Among other things, they allow pages to be shared on social media, the posting of comments, and the publication (on our site or elsewhere) of ads that reflect your centres of interest.

Our EZPublish content management system (CMS) uses CAS and PHP session cookies and the New Relic cookie for monitoring purposes (IP, response times).

These cookies are deleted at the end of the browsing session (when you log off or close your browser window)

Our EZPublish content management system (CMS) uses the XiTi cookie to measure traffic. Our service provider is AT Internet. This company stores data (IPs, date and time of access, length of the visit and pages viewed) for six months.

Our EZPublish content management system (CMS) does not use this type of cookie.

For more information about the cookies we use, contact INRA’s Data Protection Officer by email at cil-dpo@inra.fr or by post at:

INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

Menu Logo Principal logo envt small Logo INP-EI Purpan Logo UPS-Tlse3

Home page

Zone de texte éditable et éditée et rééditée

Research

Research strategy

Stratégy E3

The team's research strategy is based on a global approach integrating characterization and understanding :

  •     The mechanisms of fetal exposure to these substances, in a context of chronic and low-dose exposure, specific to environmental or food contamination.
  •     Their effects on the endocrino-metabolic and reproductive systems, following an adaptation of the organism to preserve its homeostasis.

The concepts of toxicokinetics/toxicodynamics (TK/TD) are thus applied to the model of the ovine fetus instrumented to analyze the relationship between maternal exposure to food contaminants and its effects through early markers of a disruption of endocrino-metabolic and reproductive functions.
The interest of toxicokinetic models is that they allow to simulate plasma concentrations of contaminants for different human exposure scenarios and to develop animal exposure patterns representative of human exposure for toxicological studies. The so-called toxicokinetic/toxicodynamic modeling of the relationship between systemic internal exposure to contaminants and their effects aims at predicting the effects of low-noise human exposure to contaminants.
Human biomonitoring data are used to validate TK models but also to develop population-based TK-TD approaches and to analyze the effects of exposure of women of childbearing age to contaminants on ovarian function.
The identification of the mechanisms that control exposure and effects is part of a remediation approach that aims to limit internal exposure and toxicological effects of contaminants. In this context, particular attention is paid to nuclear receptors including CAR (Constitutive Androstane Receptor) and PXR (Pregnane X Receptor) because of their involvement in many physiological processes including detoxification and lipid metabolism.

Some striking results

  •     Predicted human fetal plasma concentrations of bisphenol A glucuronide (40ng/L) are stable and reflect the cumulative amount of bisphenol A to which the mother was exposed during pregnancy (https://www.nature.com/articles/s41598-017-15646-5).
  •     The replacement of bisphenol A by bisphenol S leads to a very significant (X250) increase in plasma concentrations of active bisphenol (https://ehp.niehs.nih.gov/doi/10.1289/ehp4599).
  •     The disruption of maternal thyroid function resulting from low-noise exposure to bisphenol A affects the metabolome of specific regions of the central nervous system of the fetal sheep.